Varun Venkataramani

Collective cancer cell calcium activity drives brain metastasis

The paper shows brain metastases form gap-junction-coupled networks with coordinated calcium activity that drives proliferation and is inhibited by gap junction blockers.

Local translation drives glioblastoma heterogeneity and tumor invasion

This study identifies local translation as a driver of glioblastoma tumor microtubes and invasion by linking subcellular protein synthesis to invasive cell states.

Voxel-accurate MRI-microscopy correlation enables AI-powered prediction of brain disease states

BRIDGE correlates MRI with cellular data to predict brain disease states using deep learning and high-resolution microscopy.

Single-cell multidimensional profiling of tumor cell heterogeneity in supratentorial ependymomas

This study integrates single-cell and spatial transcriptomics with live-cell imaging to characterize tumor heterogeneity in supratentorial ependymomas, revealing distinct progenitor-like states and spatial organization patterns.

High LET Particle Therapy Targets Tumor Microtube Networks in Glioblastoma

This study investigates how high LET particle therapy affects tumor microtube networks in glioblastoma, finding that higher LET reduces TM formation and improves cell survival.

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing

This study uses retrograde tracing to characterize neuron-tumor networks in glioblastoma and shows that targeting these networks can enhance therapeutic outcomes.

Automated highly multiplexed super-resolution imaging of protein nano-architecture in cells and tissues

The paper introduces maS3TORM, a method for highly multiplexed 3D super-resolution imaging of proteins in cells and tissues, achieving sub-10 nm localization precision for up to 16 targets.

WNT vampirization by glioblastoma leads to tumor growth and neurodegeneration

This study shows glioblastoma cells deplete Wnt signaling from neurons, leading to tumor growth and neurodegeneration in Drosophila and human xenograft models.