Author

Michael Aron Lane

Drexel UniversityORCID 0000-0003-1375-6483Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:rat· 2 Assay:spatial transcriptomics· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Lyandysha V. ZholudevaiD· 4 shared Alessia NiceforoiD· 2 shared Tara A. FortinoiD· 2 shared Aaron J. CiechanoveriD· 1 shared Adam A. HalliD· 1 shared Asuka Alvarado· 1 shared Ayushi AgrawaliD· 1 shared Deepak SrivastavaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersNeuroscience

Lyandysha V. ZholudevaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Long-term Connectivity between Spinal Cord Tissue Transplants and the Injured Phrenic Motor Network

Adam A. Hall, Lyandysha V. Zholudeva, Theresa Connors, Victoria M. Spruance, Tara A. Fortino, Kayla Anne Schardien, Alessia Niceforo, Kimberly J. Dougherty, Qiang Liang, Michael Aron Lane

This study shows that embryonic spinal cord transplants improve diaphragm function after cervical SCI but lose connectivity over time, reducing long-term effectiveness.

bioRxiv · Jul 27, 2026 · PreprintNeuroscience

The cryo-EM-delineated mechanism underlying mimicry of CXCR4 agonism enables widespread stem cell neuroprotection in a mouse model of ALS

Xiaohong Sang, Haizhan Jiao, Qian Meng, Fang Xiong, Kartik S. Sundaram, Jiao Zhou, Yan Xu, Asuka Alvarado, Ruslan L. Nuryyev, Jitka Ourenik, Václav Ourednik, Iris S. Huang, Xiang Liu, Yuheng Mei, Tingli Qian, , Ziwei Huang

The paper demonstrates a synthetic dual-moiety strategy to design CXCR4 agonist peptides that mimic SDF-1, showing therapeutic benefit in a mouse model of ALS through neuroprotection.

bioRxiv · Jul 8, 2025 · PreprintNeuroscience

Challenges and Efficacy of Astrocyte-to-Neuron Reprogramming in Spinal Cord Injury: In Vitro Insights and In Vivo Outcomes

Alessia Niceforo, Lyandysha V. Zholudeva, Silvia Fernandes, Yashvi Shah, Michael Aron Lane, Liang Qiang

This study investigates the reprogramming of astrocytes to neurons in spinal cord injury, showing higher in vitro efficiency than in vivo.

bioRxiv · Mar 25, 2024 · PreprintNeuroscience

Human spinal interneurons repair the injured spinal cord through synaptic integration

Lyandysha V. Zholudeva, Tara A. Fortino, Ayushi Agrawal, Olaia F. Vila, Maggie Williams, Todd C. McDevitt, Michael Aron Lane, Deepak Srivastava

This study shows that human cervical V2a interneurons transplanted into injured spinal cords form functional synaptic connections with host tissue, improving diaphragm activity.

bioRxiv · Jan 11, 2024 · PreprintNeuroscience