Jörg R. P. Geiger

Syncytial coupling of mid-capillary pericytes underlies seizure-associated electro-metabolic signaling

The paper investigates electrical signaling between mid-capillary pericytes and endothelial cells in the neurovascular unit, showing syncytial coupling and its role in transmitting seizure-associated signals without relying on VGCCs.

The functional impact of LGI1 autoantibodies on human CA3 pyramidal neurons

This study examines the effects of LGI1 autoantibodies on human CA3 neurons using ex vivo slices, revealing increased neuronal activity and distinct mechanisms from potassium channel blockers.

Cellular and Synaptic Diversity of Layer 2-3 Pyramidal Neurons in Human Individuals

The paper characterizes neuronal and synaptic diversity in human layer 2-3 pyramidal neurons across individuals, finding that neuronal physiology varies with laminar depth while synaptic properties are consistent.

The polyamine naphthyl-acetyl spermine trihydrochloride (NASPM) lacks specificity for Ca2+-permeable AMPA receptors and suppresses seizure like activity in human brain tissue by inhibition of NMDA receptors.

This study shows NASPM inhibits NMDA receptors rather than CP-AMPARs in human brain tissue, challenging its use as a specific CP-AMPAR inhibitor and questioning its therapeutic potential.

Gamma-Oscillation Plasticity Is Mediated by Parvalbumin Interneurons

The paper demonstrates that gamma-oscillation plasticity in the hippocampus is mediated by parvalbumin interneurons through specific metabotropic signaling pathways.

Coherent multi-level network oscillations create neural filters to favor quiescence over navigation in Drosophila

The paper shows how coherent neural oscillations in Drosophila create filters that promote quiescence over navigation by hierarchically overriding locomotion-promoting networks.

NOSA, an analytical toolbox for multicellular optical electrophysiology

NOSA is an open-source software for analyzing voltage imaging data, offering tools to improve signal processing and identify temporal interactions in neural activity.

High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp

This paper introduces a high-throughput in-vitro multipatch setup for analyzing microcircuits in human brain tissue, enabling the study of synaptic connections across multiple neurons.

Network-specific synchronization of electrical slow-wave oscillations regulates sleep in Drosophila

The paper identifies delta oscillations in Drosophila's R2 network that regulate sleep, showing synchronization depends on NMDARs and input pathways, and disrupting this mechanism abolishes oscillations and impairs sleep.