Zachary A. Knight

The paper shows that NPFF neurons in the caudal brainstem control gastric emptying and intestinal transit by responding to duodenal nutrient sensing.

The paper shows that sham drinking suppresses thirst-promoting neurons and this suppression is learned and persists after drinking stops.

The paper identifies two distinct CGRP neuron populations with different roles in post-ingestive learning, showing one is involved in learning about post-ingestive effects while not affecting food consumption.

The paper identifies opposing roles of GIPR neurons in the area postrema and nucleus tractus solitarius in controlling feeding behavior and satiation.

The paper identifies distinct AP neuron subtypes that respond to different macronutrients and physiological signals, revealing their roles in satiety and homeostasis beyond nausea.

This study examines age-related changes in the calvarial geometry of C57BL/6J mice, showing significant spatial and sexual dimorphism that affects stereotaxic neurosurgery.

The paper investigates how food ingestion is encoded in the caudal nucleus of the solitary tract (cNTS) by comparing neural activity during gastric and oral food delivery in behaving animals.

The paper introduces X-TRAP, an orthogonal genetic tool for activity-dependent labeling of neurons in mice, enabling intersectional analysis of neural circuits involved in food intake.

This study identifies mitochondrial respiration genes as critical for protein sensing and GLP-1 release in enteroendocrine cells through a CRISPR screen.

This study shows that dopamine neuron responses to food and water cues are modulated by internal state, with hunger-specific amplification of food cue responses.

This paper identifies a dopamine pathway that enables flavour-nutrient learning by integrating interoceptive signals from the mouth and gut.

This study investigates how aging affects fluid homeostasis in mice, finding that older mice have impaired vasopressin production and altered thirst circuitry responses to dehydration cues.

This study shows that taste signals inhibit hunger-promoting AgRP neurons during eating, delaying satiety and increasing food intake when this inhibition is blocked.

This paper identifies a subcortical circuit linking interoception to jaw movement through VMHBDNF neurons, showing their role in regulating feeding behavior and consummatory actions.