Dhakshin Ramanathan

Cortical oscillations reflect opponent ensemble dynamics through coordinated multifrequency activity

The paper shows that multi-frequency amplitude co-fluctuations, called spectral motifs, better explain glutamatergic activity than single-frequency power, revealing opponent dynamics in cortical oscillations.

Methylphenidate-induced reductions in choice impulsivity are associated with alterations in cortico-striatal beta oscillations.

This study shows that methylphenidate reduces choice impulsivity by altering cortico-striatal beta oscillations in rats performing a reward task.

Differential glutamatergic and GABAergic responses drive divergent prefrontal cortex neural outcomes to low and high frequency stimulation

The paper investigates how low- and high-frequency brain stimulation differentially affects glutamatergic and GABAergic neurons in the prefrontal cortex of rodents.

Extended-Interval Theta Burst Stimulation Enhances Glutamatergic Plasticity and Antidepressant Effects via Reduced GABAergic Recruitment

This paper shows that extended interval theta burst stimulation (eTBS) enhances antidepressant effects by reducing GABAergic inhibition and promoting glutamatergic plasticity.

Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types

This study identifies how VP GABA and glutamate neurons modulate VTA cell types to drive approach and avoidance behaviors through distinct mechanisms.

Cognitive rehabilitation can improve brain injury-induced deficits in behavioral flexibility and impulsivity linked to impaired reward-feedback activity.

This study shows that cognitive rehabilitation improves behavioral flexibility and reduces impulsivity in rats with frontal TBI by enhancing orbitofrontal cortex activity and reward-feedback signaling.

A Generalized Reinforcement Learning-Based Deep Neural Network (GRL-DNN) Agent Model for Diverse Cognitive Constructs

This paper introduces a reinforcement learning-based deep neural network model to simulate multiple cognitive functions and demonstrates its potential as a testbench for cognitive impairment research.

Recovery of consolidation after sleep following experimental stroke - interaction of slow waves, spindles and GABA

This study shows that sleep-dependent memory processing is altered after stroke in rats, with impaired spindle coupling to slow oscillations, and that reducing GABA can restore physiological sleep states and improve recovery.

Rostral Anterior Cingulate Activations inversely relate to Reward Payoff Maximation & predict Depressed Mood

The paper develops a reward decision-making task and analyzes behavioral, computational, and neural correlates of reward maximization and melioration using EEG in 186 healthy adults.

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

This study shows that Cul3 haploinsufficiency in mice causes social and cognitive deficits, cortical volume reduction, and cytoskeletal defects, which are rescued by RhoA inhibition.

Mapping Cognitive Brain Functions at Scale

This paper introduces a mobile platform called BrainE for rapid, scalable EEG-based assessment of multiple cognitive tasks and demonstrates its reliability and sensitivity to neural plasticity and mental health symptoms.

Sleep spindles coordinate corticostriatal reactivations during the emergence of automaticity

The paper shows that sleep spindles during NREM sleep mediate corticostriatal plasticity, which is critical for the emergence of automatic behavior following training.