Author

Tamana Darwish

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

Clémence BlouetiD· 4 shared Anthony H. K. TsangiD· 2 shared Danaé Nuzzaci· 2 shared Fiona Mary GribbleiD· 2 shared Florian T. MerkleiD· 2 shared Frank M. ReimanniD· 2 shared Nicholas Heeley· 2 shared Peter KirwaniD· 2 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersNeuroscience

Clémence BlouetORCID

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4 papers

Recent·Most cited

Cav3.1 is a leucine sensor in POMC neurons mediating appetite suppression and weight loss

Anthony H. K. Tsang, Nicholas Heeley, Constanza Alcaino, Eun‐Sang Hwang, Brian Lam, Taufiq Rahman, Tamana Darwish, Danaé Nuzzaci, Richard G. Kay, Amar Sarkar, Ruiyan Wang, Nihal Basha, Austin Punnoose, Peter Kirwan, Marcella K.L. Ma, , Clémence Blouet

bioRxiv · Sep 13, 2024 · PreprintNeuroscience

Nutrient sensing in the nucleus od the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons.

Anthony H. K. Tsang, Danaé Nuzzaci, Tamana Darwish, Havish Samudrala, Clémence Blouet

The paper identifies a neural circuit in the nucleus of the solitary tract (NTS) that suppresses feeding by inhibiting AgRP neurons through leucine sensing and leptin-receptor-expressing neurons.

Molecular Metabolism · Sep 6, 2020Peer-reviewedNeuroscience

Rapid sensing of L-leucine by human and murine hypothalamic neurons: neurochemical and mechanistic insights

Nicholas Heeley, Peter Kirwan, Tamana Darwish, Marion Arnaud, Mark L. Evans, Florian T. Merkle, Frank M. Reimann, Fiona Mary Gribble, Clémence Blouet

This study identifies novel Ca2+ signaling mechanisms by which hypothalamic neurons in mice and humans rapidly respond to L-leucine, showing both activation and inhibition of specific neuron types.

Molecular Metabolism · Feb 7, 2018Peer-reviewedNeuroscience

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

Luke K. Burke, Tamana Darwish, Althea R Cavanaugh, Sam Virtue, Emma Roth, Joanna Morro, Shun-Mei Liu, Jing Xia, Jeffrey W. Dalley, Keith Burling, Streamson C. Chua, Toni Vidal-Puig, Gary J. Schwartz, Clémence Blouet

This study shows mTORC1 in AGRP neurons integrates food-related cues to control iBAT thermogenesis in mice, linking energy availability to adaptive energy expenditure.

eLife · May 22, 2017Peer-reviewedNeuroscience