Author

Ivy K. Hughes

Boston University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Organism:chicken / avian· 1 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Hisashi AkiyamaiD· 2 shared James B. HoodiD· 2 shared Suryaram GummuluruiD· 2 shared Alice TelesnitskyiD· 1 shared Andrés A. Quiñones-MolinaiD· 1 shared Andrew J. HendersoniD· 1 shared Sallieu Jalloh· 1 shared Siarhei KharytonchykiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMicrobiology

Hisashi AkiyamaORCID

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2 papers

Recent·Most cited

MicrobiologyScience AdvancesPeer-reviewedNov 12, 2025

Evasion of CARD8 Activation During HIV-1 Assembly

Ivy K. Hughes, James B. Hood, Andrés A. Quiñones-Molina…·Suryaram Gummuluru

This study shows HIV-1 Gag suppresses CARD8 activation by controlling protease timing, and host-adaptive mutations in Gag help evade CARD8-mediated cell death.

3 citations

humanchicken / avian

𝕏 PostBluesky

MicrobiologybioRxivPreprintAug 20, 2025

5' cap sequestration is required for sensing of unspliced HIV-1 RNA by MDA5

Ivy K. Hughes, Siarhei Kharytonchyk, Sita Ramaswamy…·Suryaram Gummuluru

This study shows that MDA5 senses HIV-1 unspliced RNA based on 5' cap structure and nuclear export pathway, revealing how the virus evades innate immunity.

2 citations

humanmetagenomics

𝕏 PostBluesky