Author

Tuomo Laitinen

University of Eastern FinlandORCID 0000-0003-1539-2142Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 3 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Christopher R. M. AsquithiD· 4 shared Antti PosoiD· 3 shared Gary L. JohnsoniD· 2 shared Graham J. TizzardiD· 2 shared Michael P. EastiD· 2 shared Aditi AgrawaliD· 1 shared Alison D. AxtmaniD· 1 shared Amrita OjhaiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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4 shared papersPharmacology & Toxicology

Christopher R. M. AsquithORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintAug 20, 2026

Discovery and optimization of the next generation of cell active Protein Kinase Novel 3 (PKN3) inhibitors

Eleni Georgiou, Tuomo Laitinen, Antti Poso…·Christopher R. M. Asquith

This study identifies and optimizes a submicromolar PKN3 inhibitor, 6e (URS03-06), for cellular biology research.

DOI 10.64898/2026.08.20.745975

experimental assaydrug response / drug discovery

𝕏 PostBluesky

MicrobiologyNature CommunicationsPeer-reviewedJul 10, 2025

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

Marwah Karim, Manjari Mishra, Chieh‐Wen Lo…·Shirit Einav

RMC-113 inhibits PIP4K2C and PIKfyve, reversing SARS-CoV-2-induced autophagic flux impairment and showing antiviral effects.

19 citationstop 1%

humanorganoid / primary culture

𝕏 PostBluesky

Pharmacology & ToxicologyEuropean Journal of Medicinal ChemistryPeer-reviewedApr 1, 2024

Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships

Christopher R. M. Asquith, Michael P. East, Tuomo Laitinen…·Gary L. Johnson

The paper identifies and optimizes narrow-spectrum TLK2 inhibitors using QSAR analysis and structural studies.

4 citations

statistical modeldrug response / drug discovery

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintFeb 11, 2019

Design and evaluation of novel 4-anilinoquinolines and quinazolines as EGFR inhibitors in lung cancer and chordoma

Christopher R. M. Asquith, Kaitlyn A. Maffuid, Tuomo Laitinen…·William J. Zuercher

The paper designs and evaluates novel 4-anilinoquinolines and quinazolines as EGFR inhibitors, identifying a potent compound for lung cancer and chordoma treatment.

DOI 10.1101/545525

humanexperimental assay

𝕏 PostBluesky