Author
UCL Queen Square Institute of NeurologyORCID 0000-0003-1675-642XUnclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Dimitris Kotzadimitriou, Helen Langley, Eleanor McGowan…·Kirill E. Volynski
Krisha Aghi, Ryan Schultz, Zachary L. Newman…·Ehud Y. Isacoff
The paper shows that synaptic release probability varies across synapses but remains constant overall due to balanced facilitation and depression.
Julia Bleier, Philipe R. F. Mendonça, Chris H. Habrian…·Ehud Y. Isacoff
This study uses smFRET to analyze GluN1 conformational changes in NMDA receptors with different GluN2 subunits, revealing subtype-specific allosteric control mechanisms.
Philipe R. F. Mendonça, Erica Tagliatti, Helen Langley…·Kirill E. Volynski
The paper quantifies asynchronous glutamate exocytosis in synapses, showing it is enhanced in low release probability synapses and more widely dispersed than synchronous release.
Erica Tagliatti, Oscar Daniel Bello, Philipe R. F. Mendonça…·Kirill E. Volynski
This study shows that Syt1 oligomerisation is essential for clamping spontaneous and asynchronous neurotransmitter release, revealing a mechanism for regulating release modes.