A multivalent adaptor mechanism drives the nuclear import of proteasomes
Hanna L. Brunner, Robert Kalis, Lorenz Grundmann, Zuzana Hodáková, Zuzana Koskova, Irina Grishkovskaya, Melanie de Almeida, Matthias Hinterndorfer, Hannah Knaudt, Simon Höfflin, Florian Andersch, Harald Kotisch, Achim Dickmanns, Sara Cuylen‐Haering, Johannes A. Zuber, David Haselbach
The paper identifies AKIRIN2 as a multivalent adaptor protein that coordinates proteasome nuclear import through a stepwise assembly of importin clusters.
Nature Communications · Feb 4, 2026Peer-reviewedMolecular Biology