Félix Leroy

The paper examines how aging affects engram cell distribution, stability, and gene expression in mice, finding altered engram allocation and distinct transcriptional patterns in aged brains.

This study identifies a ventral CA2 region in the hippocampus that promotes social aggression but not social memory, distinguishing it from the dorsal CA2 region.

This study identifies a novel interhemispheric CA1 projection to the dorsal subiculum that supports spatial memory and is disrupted in a mouse model of 22q11.2 deletion syndrome.

This study investigates how HCN1 channels in parvalbumin-positive interneurons regulate GABA release in hippocampal CA1, showing that HCN1 enhances inhibitory transmission.

This study presents two genetic mouse models of HCN1 epileptic encephalopathy, showing seizure susceptibility and adverse drug responses, highlighting the need for tailored therapies.

The paper identifies CRH-expressing inhibitory neurons in the prefrontal cortex that project to the lateral septum, showing their role in suppressing interactions with familiar mice and supporting social novelty preference.

The paper identifies a direct lateral entorhinal cortex to hippocampal CA2 circuit that conveys social information necessary for social memory, distinct from novelty detection pathways.

This paper identifies a novel vCA1[->]pPVN circuit that modulates both learned and innate fear by regulating neuronal activity in the PAG.

This study shows that CA2 ripples during sleep replay social exploration experiences, and disrupting or enhancing these ripples affects social memory consolidation.