Ángel Barco

Aging alters the distribution, stability, and transcriptional signature of engram cells

The paper examines how aging affects engram cell distribution, stability, and gene expression in mice, finding altered engram allocation and distinct transcriptional patterns in aged brains.

Dynamic Modulation of Neural Cell Identity Maintenance via Lysine Acetyltransferase Type 3 Protein Targeted Degradation

This study shows that KAT3 proteins are essential for maintaining neural cell identity, and their degradation or restoration affects transcriptome and physiological functions in neuronal and glial cells.

KAT3 Shuttling Between Neuronal Identity and Activity-Dependent Plasticity Programs Drives Large-Scale Chromatin Remodeling

The paper shows that KAT3 cofactors move between neuronal identity and activity-dependent plasticity programs, causing chromatin remodeling in hippocampal neurons.

Inflammation-induced epigenetic memory restores oligodendrocyte progenitor cell regenerative capacity in the aged central nervous system

This study shows that inflammation-induced epigenetic memory in OPCs improves remyelination in aged mice by enhancing differentiation and reducing axonal damage.

Systematic review and transcriptomic meta-analysis of environmental enrichment reveal core molecular programs of brain plasticity

This study performs a systematic review and transcriptomic meta-analysis of environmental enrichment in rodents, identifying core molecular programs associated with brain plasticity.

Rearing conditions bidirectionally modulate cognitive abilities and AP-1 signaling in hippocampal neurons in a cell type-specific manner.

The paper shows that environmental enrichment and impoverishment affect cognitive abilities and AP-1 signaling in hippocampal neurons differently depending on cell type.

Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

This study identifies GluN3A-NMDA receptors as negative regulators of GIT1/mTORC1 assembly, showing their role in controlling synaptic protein synthesis and memory formation.

Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis

The paper identifies sublayer- and cell-type-specific transcriptional changes in hippocampal sclerosis using single-nucleus and bulk RNA sequencing, revealing distinct neurodegenerative trajectories in superficial CA1 neurons.

Zic2 abrogates an alternative Wnt signaling pathway to convert axon attraction into repulsion

The paper identifies an alternative Wnt signaling pathway regulated by Zic2 that mediates axon repulsion by modulating β-catenin phosphorylation and Eph signaling.

Immediate and deferred epigenomic signature of neuronal activation

The paper investigates transcriptional and chromatin changes in hippocampal neurons during and after activation, identifying immediate and long-term epigenomic signatures linked to neuroplasticity.