Elke Vandewyer

DeorphaNN identifies peptide agonists for GPCRs using AlphaFold structural predictions and deep learning embeddings, successfully uncovering agonists for two orphan receptors across species.

This study identifies a thyrostimulin-like neuroendocrine pathway in C. elegans that regulates growth and intestinal function through GPA2/GPB5 signaling.

The paper reports a genome-wide map of neuropeptide-GPCR interactions in C. elegans, identifying 461 cognate peptide-GPCR pairs and uncovering their evolutionary conservation.

The paper identifies and functionally characterizes a novel overlapping gene azyx-1 in C. elegans, showing its role in regulating zyx-1 proteoforms and affecting muscular integrity and locomotion.

The paper identifies neuromodulatory circuits in C. elegans that control sickness behavior dynamics during infection by Pseudomonas aeruginosa.

The paper identifies a male-specific neuropeptide-receptor module that drives a sex-specific behavioral response to the pheromone ascr#8 in C. elegans.

The paper identifies extrasynaptic volume transmission as a non-synaptic signaling route in nematodes, showing that neuropeptides in pseudocoelomic fluid modulate reproductive function and behavior.

The paper identifies neuromedin U (NMU) signaling as critical for memory retrieval of learned salt avoidance in C. elegans, showing its role in modulating navigational strategies through specific neurons.