Isabel Beets

The paper identifies an autocrine feedback mechanism in C. elegans AVK neurons that regulates neuropeptide expression and secretion through FLP-1 and DMSR-7 interactions.

This study identifies a membrane potential-independent role for the K2P channel TWK-40 in regulating presynaptic organisation through intracellular potassium levels and interactions with PYK-1 and transcription factors.

DeorphaNN identifies peptide agonists for GPCRs using AlphaFold structural predictions and deep learning embeddings, successfully uncovering agonists for two orphan receptors across species.

This study creates a gene expression atlas of C. elegans L1 neurons, identifying differentially expressed genes and regulatory networks involved in postembryonic neurogenesis and maturation.

The paper analyzes whole-animal single-cell transcriptomes of nematodes to reveal stable neuronal identities but divergent signaling pathways across species.

This study identifies 2143 flp-genes across 100+ nematode species, revealing evolutionary patterns and expression dynamics of FLPs in parasitic nematodes.

The paper shows two neuropeptides from a single neuron pair in C. elegans have opposing effects on locomotion, with one inhibiting the release of the other through autocrine feedback.

This study identifies FSHR-1 as a key receptor mediating cell non-autonomous regulation of synaptic transmission in C. elegans through inter-tissue signaling.

This study identifies a thyrostimulin-like neuroendocrine pathway in C. elegans that regulates growth and intestinal function through GPA2/GPB5 signaling.

The paper reports a genome-wide map of neuropeptide-GPCR interactions in C. elegans, identifying 461 cognate peptide-GPCR pairs and uncovering their evolutionary conservation.

The paper generates a draft connectome of neuropeptide signaling in C. elegans by integrating single-cell data with biochemical analysis.

The paper shows how C. elegans integrates food and temperature inputs through multisite gating in sensory circuits to control persistent behavioral states.

The paper identifies neuromodulatory circuits in C. elegans that control sickness behavior dynamics during infection by Pseudomonas aeruginosa.

This study identifies a sex-specific role of the lury-1 neuropeptide in feeding and mating behaviors of male C. elegans.

The paper shows that the NLP-12 neuropeptide system in C. elegans modulates head and body motor circuits through CKR-1 and CKR-2 GPCRs to regulate food search behavior.

The paper identifies a male-specific neuropeptide-receptor module that drives a sex-specific behavioral response to the pheromone ascr#8 in C. elegans.

The paper identifies extrasynaptic volume transmission as a non-synaptic signaling route in nematodes, showing that neuropeptides in pseudocoelomic fluid modulate reproductive function and behavior.

The paper identifies neuromedin U (NMU) signaling as critical for memory retrieval of learned salt avoidance in C. elegans, showing its role in modulating navigational strategies through specific neurons.

The paper identifies genes that constrain dendrite growth in C. elegans throughout life, revealing a mechanism distinct from developmental growth pathways.