Author

Cailin E. Deal

Ragon Institute of MGH, MIT and Harvard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrea Carfı́iD· 2 shared Obadiah J. Plante· 2 shared Adam D. NitidoiD· 1 shared Alejandro Benjamin BalazsiD· 1 shared Allen Z. LiniD· 1 shared Amarendra PeguiD· 1 shared Benjamin MooniD· 1 shared Christine L. BoutrosiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Andrea Carfı́ORCID

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3 papers

Recent·Most cited

HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV vectored immunotherapy in humanized mice

Nicolás M. S. Gálvez, Adam D. Nitido, Seo Bin Yoo, Yi Cao, Cailin E. Deal, Christine L. Boutros, Scott W. MacDonald, Yentli E. Soto Albrecht, Evan Christopher Lam, Maegan L. Sheehan, Dylan Parsons, Allen Z. Lin, Martin J. Deymier, Jacqueline M. Brady, Benjamin Moon, , Alejandro Benjamin Balazs

This paper uses humanized mice to study how HIV resistance to broadly neutralizing antibodies (bNAbs) affects the efficacy of AAV-delivered immunotherapy, finding that escape mutation fitness costs and resistance benefits determine therapeutic success.

Immunity · Feb 25, 2026Peer-reviewedMicrobiology

Harnessing mRNA for the expression of monoclonal IgG and IgA in non-human primates.

Romy Rouzeau, Hayden R. Schmidt, Cailin E. Deal, Joel D. Allen, Dawn M. Dudley, Iszac Burton, Eva G. Rakasz, Obadiah J. Plante, Max Crispin, Andrea Carfı́, Devin Sok

This paper demonstrates the feasibility of expressing monoclonal IgG and IgA antibodies in non-human primates using mRNA-LNPs, showing both isotypes retain HIV-neutralizing function and native-like glycosylation.

Frontiers in Immunology · Jan 16, 2026Peer-reviewedImmunology

Maternal transfer of mRNA LNP-derived, pathogen-specific, monoclonal IgG to suckling mice

Jennifer E. Doering, Yetunde Adewunmi, Cailin E. Deal, Obadiah J. Plante, Andrea Carfı́, Nicholas John Mantis

This study demonstrates that mRNA-LNPs can deliver pathogen-specific monoclonal IgG into breast milk, enabling transfer of functional antibodies to suckling mice.

bioRxiv · Mar 12, 2025 · PreprintImmunology