Joseph M. Muretta

This paper introduces a physics-aware deep clustering method to identify heterogeneous folding domains in single-molecule force spectroscopy data, revealing distinct mechanical properties in natural proteins.

This paper introduces programmable antibody-DNA conjugation methods using HUH-tags to enable quantitative measurement of receptor-specific adhesion dynamics in cancer cells and NK cells.

This study identifies ABCB1-mediated drug efflux as a mechanism of resistance to VpreB1-targeted antibody-drug conjugates in B-cell lymphoblastic leukemia and suggests strategies to overcome this resistance.

This study investigates how phosphorylation at Y211 regulates KIF11's mechanical properties during mitosis, showing it modulates motor velocity, force generation, and spindle dynamics.

This study compares the mechanical properties of dystrophin and utrophin fragments using AFM, finding bacterial utrophin is less stiff than insect utrophin, while dystrophin is intermediate.

This study develops a Notch inhibitory nanobody and demonstrates a strategy to enhance its efficacy through fusion with an Aerolysin domain.

The paper uses TR-FRET to directly measure the correlation between the interacting-heads motif (IHM) and super-relaxed state (SRX) in myosin, finding that SRX is more stabilized by mavacamten than IHM.