Author

Pablo Llévenes

Boston UniversityORCID 0000-0003-1925-7204Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Andrew CheniD· 3 shared Gerald V. DenisiD· 3 shared Michael SeeniD· 3 shared Stefano MontiiD· 3 shared Yuhan QiuiD· 3 shared Alejandro Nico Rondón-OrtiziD· 1 shared Christina S. EnnisiD· 1 shared Devin SteenkampiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

Andrew ChenORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Metabolic dysfunction and metformin modify plasma extracellular vesicle signaling to prostate cancer cells

Michael Seen, Pablo Llévenes, Heejoo Kang, Yuhan Qiu, Christina S. Ennis, Andrew Chen, Sara M. Alexanian, Devin Steenkamp, Stefano Monti, Gerald V. Denis

This study investigates how metabolic dysfunction and metformin affect plasma extracellular vesicle signaling to prostate cancer cells, identifying specific miRNAs and their effects on tumor progression.

bioRxiv · Nov 1, 2026 · PreprintCancer Biology

Plasma Exosomes in Insulin Resistant Obesity Exacerbate Progression of Triple Negative Breast Cancer

Pablo Llévenes, Andrew Chen, Matthew L. Lawton, Alejandro Nico Rondón-Ortiz, Yuhan Qiu, Michael Seen, Stefano Monti, Gerald V. Denis

This study shows that plasma exosomes from obese mice enhance TNBC aggressiveness by inducing epithelial-mesenchymal transition and Rac1 activation.

BMC Cancer · Jul 9, 2025Peer-reviewedCancer Biology

Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes

Yuhan Qiu, Andrew Chen, Rebecca Yu, Pablo Llévenes, Michael Seen, Naomi Yu Ko, Stefano Monti, Gerald V. Denis

This study shows insulin-resistant adipocyte exosomes promote TNBC aggressiveness and brain metastasis via miRNA pathways.

Molecular Cancer Research · Mar 6, 2025Peer-reviewedCancer Biology