Michael Seen

This study investigates how metabolic dysfunction and metformin affect plasma extracellular vesicle signaling to prostate cancer cells, identifying specific miRNAs and their effects on tumor progression.

This study investigates how AMPK and BET proteins regulate immune checkpoint molecules in TNBC patients with T2D, suggesting personalized ICB treatment strategies.

This study shows that exosomes from type 2 diabetes patients promote breast cancer aggressiveness in organoids by expanding immunosuppressive cells and increasing tumor heterogeneity and invasiveness.

This study shows that plasma exosomes from obese mice enhance TNBC aggressiveness by inducing epithelial-mesenchymal transition and Rac1 activation.

This study shows insulin-resistant adipocyte exosomes promote TNBC aggressiveness and brain metastasis via miRNA pathways.