Andrew Chen

This study investigates how metabolic dysfunction and metformin affect plasma extracellular vesicle signaling to prostate cancer cells, identifying specific miRNAs and their effects on tumor progression.

This paper introduces a benchmarking framework for predicting perturbation signatures across biological contexts, showing that projection and network-based methods perform well across diverse datasets and contexts.

This study shows that environmental chemical mixtures disrupt mammary development and induce epigenetic changes linked to breast cancer, particularly invasive lobular carcinoma.

The paper integrates six single-cell datasets to create a high-resolution atlas of HPV-negative HNSCC, revealing new cell populations and associations between transcriptional signatures and clinical outcomes.

This study creates a large integrated single-cell RNA-seq atlas of human breast cancers, revealing tumor microenvironment heterogeneity and survival-associated cell states across multiple datasets.

This study shows that exosomes from type 2 diabetes patients promote breast cancer aggressiveness in organoids by expanding immunosuppressive cells and increasing tumor heterogeneity and invasiveness.

This study shows that plasma exosomes from obese mice enhance TNBC aggressiveness by inducing epithelial-mesenchymal transition and Rac1 activation.

This study shows insulin-resistant adipocyte exosomes promote TNBC aggressiveness and brain metastasis via miRNA pathways.