Gerald V. Denis

This study investigates how metabolic dysfunction and metformin affect plasma extracellular vesicle signaling to prostate cancer cells, identifying specific miRNAs and their effects on tumor progression.

This study investigates how AMPK and BET proteins regulate immune checkpoint molecules in TNBC patients with T2D, suggesting personalized ICB treatment strategies.

This study creates a large integrated single-cell RNA-seq atlas of human breast cancers, revealing tumor microenvironment heterogeneity and survival-associated cell states across multiple datasets.

This study shows that exosomes from type 2 diabetes patients promote breast cancer aggressiveness in organoids by expanding immunosuppressive cells and increasing tumor heterogeneity and invasiveness.

This study shows that plasma exosomes from obese mice enhance TNBC aggressiveness by inducing epithelial-mesenchymal transition and Rac1 activation.

This study shows insulin-resistant adipocyte exosomes promote TNBC aggressiveness and brain metastasis via miRNA pathways.

The paper maps EMT transitions through multi-omic profiling, identifies key regulatory factors, and reveals discordance between molecular layers in human mammary epithelial cells.