The paper uses spatial transcriptomics to analyze Aβ plaques and glial interactions in AD brains, finding that low Aβ areas show more neuronal loss and high-glia areas show inflammation and neurodegeneration.

Molecular Neurodegeneration Advances · Jul 16, 2025Peer-reviewedGenomics

Structural variants linked to Alzheimer's Disease and other common age-related clinical and neuropathologic traits

Ricardo A. Vialle, Kátia de Paiva Lopes, Yan Li, Bernard Ng, Julie A. Schneider, Aron S. Buchman, Yanling Wang, José M. Farfel, Lisa Laverne Barnes, Aliza P. Wingo, Thomas S. Wingo, Nicholas T. Seyfried, Philip L. De Jager, Chris Gaiteri, Shinya Tasaki, David Alan Bennett

The paper investigates structural variants (SVs) in AD/ADRD traits using whole genome sequencing data from two cohort studies, identifying SVs linked to disease phenotypes and suggesting new risk loci.

Genome Medicine · Mar 4, 2025Peer-reviewedGenetic & Genomic Medicine

The YTHDF proteins shape the brain gene signatures of Alzheimer's disease

Shinya Tasaki, Denis R. Avey, Nicola A. Kearns, Chunjiang Yu, Sashini L De Tissera, Himanshu Vyas, Lin Cheng, Jishu Xu, Artemis Iatrou, Daniel J. Flood, Wenlong Li, Lisa Laverne Barnes, Katherine L. Rothamel, Aliza P. Wingo, Thomas S. Wingo, , Yanling Wang

This study identifies YTHDF proteins as key regulators of Alzheimer's disease brain gene signatures through m6A-dependent and independent mechanisms.

bioRxiv · Oct 23, 2024 · PreprintNeuroscience

Bulk and Single-nucleus Transcriptomics Highlight Intra-telencephalic and Somatostatin Neurons in Alzheimer's Disease

Micaela Elisa Consens, Yuxiao Chen, Vilas Menon, Yanling Wang, Julie A. Schneider, Philip L. De Jager, David Alan Bennett, Shreejoy J. Tripathy, Daniel Felsky

The paper identifies somatostatin and intra-telencephalic neurons as significantly associated with Alzheimer's disease using bulk and single-nucleus transcriptomics across multiple datasets.

Frontiers in Molecular Neuroscience · Jun 10, 2022Peer-reviewedNeuroscience