Meike Jakobi

This paper develops nanobodies targeting hOX40 for in vivo imaging of activated T cells, showing they bind specifically and function as imaging probes without affecting T cell viability.

This study shows that LRRK2 G2019S mutation interacts with low-grade inflammation and aging to promote gut and peripheral immune activation before nigrostriatal degeneration in mice.

This study shows that IFN-γ and LRRK2 synergize in human neurons and microglia, leading to defects in neurite elongation and microglial activation.