Xihe Liu

The paper identifies cardiac progenitors as a source of Wnts that regulate second heart field development through secretion, using genetic manipulation and single-cell RNA sequencing in mice.

This paper describes a mouse model with 100% penetrance of AVSD by introducing conditional SHH pathway mutations in a trisomic DS model.

This study shows noncanonical Notch signaling has stage-specific roles in cardiac development, inhibiting early heart formation but promoting later growth.