Fabrizia Cesca

This study identifies Kidins220 as critical for NSC survival and adult neurogenesis by regulating AKT and GSK3 activity in response to growth factors.

This study shows that astrocytes switch from a kinase-based to a calcium-based response to BDNF during development, with Kidins220/ARMS modulating both pathways and regulating Kir4.1 expression.

This study shows that enhancing neuronal activity rescues developmental defects in Mecp2 null neurons, improving their maturation and extending lifespan in a mouse model of Rett syndrome.