Gian Michele Ratto

This study shows that mTOR signalling, not clock gene rhythms, drives daily physiological variations in mammals and plants.

The paper introduces iClima, a ratiometric genetically encoded sensor for imaging GABAergic chloride currents, showing it can detect Cl- transients in vitro and in vivo with improved photostability and pH independence.

This study shows sleep deprivation impairs information processing in the prefrontal cortex by disrupting chloride homeostasis through KCC2 reduction and BDNF-TrkB signaling, which can be mitigated by bumetanide or AP synthesis blockade.

This study shows acute stress impairs sensorimotor gating by increasing allopregnanolone in the prefrontal cortex, which can be reversed by blocking allopregnanolone.

The paper shows that intracellular chloride levels in cortical pyramidal cells vary diurnally, affecting neuronal network stability and seizure latency.

The paper introduces Beatrix, a tool to amplify weak Cre activity for generating and detecting genetic mosaics in vivo.

This study shows that enhancing ERK2 signalling protects neurons and improves memory in mouse models of neurodegenerative diseases.

This study shows that perineuronal nets (PNNs) in the adult mouse visual cortex regulate thalamic recruitment of PV interneurons, affecting visual processing and plasticity.

This study uses chemogenetic-fMRI to identify brain regions activated by serotonergic stimulation, showing region-specific effects rather than global activity changes.