Thomas C. Darton

This study shows that typhoid toxin from Salmonella Typhi triggers DNA damage responses, leading to antimicrobial effects like lysozyme secretion that inhibit bacterial virulence.

The paper introduces TyphiNET, a dashboard for exploring Typhi genomics data to support public health decisions on antimicrobial resistance and vaccine implementation.

This paper introduces RGStraP, a tool to infer genetic population structure from RNAseq data and shows it can control for population structure in gene expression analyses.

The paper identifies genetic variants and HLA types associated with susceptibility to enteric fever in human volunteers challenged with Salmonella.

The paper identifies a host gene signature using machine learning to distinguish enteric fever from other febrile diseases with high accuracy.