Kathryn A. O’Donnell

The paper identifies a KRT13+ hillock-like cell state in LUSC, driven by KLF4, which contributes to therapeutic resistance and heterogeneity.

The paper shows that the integrated stress response (ISR) coordinates the translation of PD-L1 and CD155, two immune checkpoint proteins, in lung cancer, and suggests combining ISR inhibition with PD-1 blockade as a therapeutic strategy.

This study shows that TMPRSS11B promotes an acidified and immunosuppressive tumor microenvironment in lung squamous cell carcinoma, suggesting it as a therapeutic target.