Author

Shruthy Suresh

Institute of Genomics and Integrative BiologyORCID 0000-0002-2985-8284Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Aanchal Yadav· 1 shared Ariana ArceiD· 1 shared Ayesha NasreeniD· 1 shared Ayush AggarwaliD· 1 shared Babita SharmaiD· 1 shared Bhashkar Paul· 1 shared Bret M. EversiD· 1 shared Cheryl M. LewisiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Aanchal Yadav

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2 papers

Recent·Most cited

Mgat4b mediated selective N-glycosylation regulates melanocyte development and melanoma progression

Babita Sharma, Keerthic Aswin, Tanya Jain, Ayesha Nasreen, Ayush Aggarwal, Yogaspoorthi J. Subramaniam, Jeyashri Rengaraju, Srashti Jyoti Agrawal, Mayank Bhatt, Bhashkar Paul, Koushika Chandrasekaran, Aanchal Yadav, Jyoti Soni, Rajat Ujjainiya, Md Quasid Akhter, , Vivek T. Natarajan

This study identifies Mgat4b as a regulator of melanocyte development and melanoma progression through N-glycosylation, showing its role in cell migration, adhesion, and tumor initiation.

Proceedings of the National Academy of Sciences · May 27, 2025Peer-reviewedCancer Biology

Coordinated translational control of multiple immune checkpoints by the integrated stress response pathway in lung cancer

Shayna Elizabeth Thomas-Jardin, Shruthy Suresh, Ariana Arce, Nicole Novaresi, Qing Deng, Emily Stein, Lisa Thomas, Cheryl M. Lewis, Chul Woo Ahn, Bret M. Evers, Esra A. Akbay, Maria Esther Salvatierra, Wei Lü, Khaja B. Khan, Luisa M. Solis Soto, , Kathryn A. O’Donnell

The paper shows that the integrated stress response (ISR) coordinates the translation of PD-L1 and CD155, two immune checkpoint proteins, in lung cancer, and suggests combining ISR inhibition with PD-1 blockade as a therapeutic strategy.

Cancer Research · May 6, 2025Peer-reviewedCancer Biology