Cancer BiologyCancer ResearchPeer-reviewed
Coordinated translational control of multiple immune checkpoints by the integrated stress response pathway in lung cancer
Shayna Elizabeth Thomas-Jardin, Shruthy Suresh, Ariana Arce…·Kathryn A. O’Donnell
The paper shows that the integrated stress response (ISR) coordinates the translation of PD-L1 and CD155, two immune checkpoint proteins, in lung cancer, and suggests combining ISR inhibition with PD-1 blockade as a therapeutic strategy.
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