Author

Martha S. Jordan

Parker Institute for Cancer ImmunotherapyORCID 0000-0003-2359-3227Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. John WherryiD· 2 shared Hua HuangiD· 2 shared Josephine Ruth GilesiD· 2 shared Aditi ChandraiD· 1 shared Alexander Chan Chi HuangiD· 1 shared Alexander J. DimitriiD· 1 shared Alexander T. DilsiD· 1 shared Amy E. BaxteriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

E. John WherryORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintJan 29, 2026

Precision CRISPR annotation of the functional enhancer landscape in primary human T cells

Ping Wang, Josephine Ruth Giles, Hua Huang…·E. John Wherry

The paper develops a CRISPRi platform to annotate functional enhancers in human T cells, identifying novel CREs and their regulatory roles in immune responses.

DOI 10.64898/2026.01.27.702006

humangenetic perturbation / CRISPR

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ImmunologyScience AdvancesPeer-reviewedNov 13, 2024

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

Alexander J. Dimitri, Amy E. Baxter, Gregory M. Chen…·Joseph A. Fraietta

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

42 citationstop 2%

mouseCITE-seq

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ImmunologybioRxivPreprintJun 7, 2024

Akt2 deficiency impairs Th17 differentiation, augments Th2 differentiation, and alters the peripheral response to immunization

Lauren Baker Banks, Tammarah Sklarz, Mercy Gohil…·Martha S. Jordan

This study shows Akt2 deficiency impairs Th17 differentiation, enhances Th2 differentiation, and reduces peripheral immune responses to immunization.

1 citation

mouseexperimental assay

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