Author

Nicholas J. C. Smith

Women's and Children's HospitalORCID 0000-0003-2409-9239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alejandro Metke· 1 shared Alessandra BrayiD· 1 shared Alison G. ComptoniD· 1 shared Ann E. FrazieriD· 1 shared Ann-Maree Huang· 1 shared AnneMarie E. WelchiD· 1 shared Austin R. Nelson· 1 shared Belinda ChongiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperGenetic & Genomic Medicine

Alejandro Metke

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Structural characterization of antibody-responses from Zolgensma treatment provides the blueprint for the engineering of an AAV capsid suitable for redosing

Mario Mietzsch, Jane Hsi, Austin R. Nelson, Neeta Khandekar, Ann-Maree Huang, Nicholas J. C. Smith, Jon Zachary, Lindsay Potts, Michelle Anne Farrar, Paul R. Chipman, Mohammad Ghanem, Ian E. Alexander, Grant J. Logan, Juha T. Huiskonen, ROBERT V. McKENNA

This study uses cryo-EM to analyze antibodies against AAV9 vectors, identifying residues that enable capsid engineering to avoid neutralization and allow redosing.

Nature Communications · Apr 19, 2025Peer-reviewedImmunology

The Australian Genomics Mitochondrial Flagship: A National Program Delivering Mitochondrial Diagnoses

Rocío Rius, Alison G. Compton, Naomi L. Baker, Shanti Balasubramaniam, Stephanie Best, Kaustuv Bhattacharya, Kirsten Boggs, Tiffany F. Boughtwood, Jeffrey Braithwaite, Drago Bratkovic, Alessandra Bray, Marie‐Jo Brion, Jo Burke, Sarah Casauria, Belinda Chong, , David Ross Thorburn

The paper evaluates the diagnostic effectiveness of genomic sequencing in mitochondrial diseases using blood samples, finding a 55% diagnostic yield with higher rates in pediatric cases.

Genetics in Medicine · Sep 19, 2024Peer-reviewedGenetic & Genomic Medicine