Author

Nathalie Gueguen

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 6 Approach:experimental assay· 6 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

Émilie BrassetiD· 6 shared Abdou AkkoucheiD· 3 shared Stéphanie Maupetit‐MehouasiD· 3 shared Antoine BoiviniD· 2 shared Benjamin BertiniD· 2 shared Benjamin Czech· 2 shared Gregory J. HannoniD· 2 shared Karine CasieriD· 2 shared

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2019-2025 · peak 2/yr

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10 top collaborators · 25 mutual co-author links

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6 shared papersGenetics

Émilie BrassetORCID

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6 papers

Recent·Most cited

The transcription factor Traffic jam orchestrates the somatic piRNA pathway in Drosophila ovaries

Azad Alizada, Aline Martins, Nolwenn Mouniée, Julia V. Rodriguez Suarez, Benjamin Bertin, Nathalie Gueguen, Vincent Mirouse, Anna Maria Papameletiou, Austin J Rivera, Nelson C. Lau, Abdou Akkouche, Stéphanie Maupetit‐Mehouas, Gregory J. Hannon, Benjamin Czech, Émilie Brasset

This study identifies Traffic jam as a master regulator of the somatic piRNA pathway in Drosophila ovaries, showing its role in controlling piRNA factors and the flamenco cluster.

Cell Reports · Apr 1, 2025Peer-reviewedMolecular Biology

A dual histone code specifies the binding of heterochromatin protein Rhino to a subset of piRNA source loci

Abdou Akkouche, Emma Kneuss, Susanne Bornelöv, Yoan Renaud, Evelyn L. Eastwood, Jasper van Lopik, Nathalie Gueguen, Mingxuan Jiang, Pau Creixell, Stéphanie Maupetit‐Mehouas, Anna Sobieszek, Yifan Gui, Benjamin Czech, Émilie Brasset, Gregory J. Hannon

The paper identifies a dual histone modification (H3K9me3 and H3K27me3) that specifies Rhino binding to a subset of piRNA source loci in Drosophila germ cells, independent of Kipferl.

bioRxiv · Jan 11, 2024 · PreprintMolecular Biology

Gap junction and amino acid import in somatic cells promote germ cell growth

Caroline Vachias, Camille Tourlonias, Louis Grelée, Nathalie Gueguen, Yoan Renaud, Parvathy Venugopal, Graziella Richard, Pierre Pouchin, Émilie Brasset, Vincent Mirouse

The paper shows that gap junctions and amino acid import in somatic cells support germ cell growth in Drosophila by enabling metabolic transfer and regulating translation.

bioRxiv · May 15, 2023 · PreprintDevelopmental Biology

The histone demethylase KDM3 prevents auto-immune piRNAs production in Drosophila

Karine Casier, Julie Autaa, Nathalie Gueguen, Valérie Delmarre, Pauline P. Marie, Stéphane Ronsseray, Clément Carré, Émilie Brasset, Laure Teysset, Antoine Boivin

The paper identifies KDM3 as a histone demethylase that prevents auto-immune piRNA production from gene-containing regions in Drosophila by inhibiting piRNA cluster formation.

Science Advances · Apr 7, 2023Peer-reviewedGenetics

Reactivation of an errantivirus in Drosophila ovarian somatic tissue: from germline invasion to taming

Marianne Yoth, Stéphanie Maupetit‐Mehouas, Abdou Akkouche, Nathalie Gueguen, Benjamin Bertin, Silke Jensen, Émilie Brasset

This study reactivates an errantivirus in Drosophila somatic cells, showing it can invade oocytes and trigger a germline immune response.

bioRxiv · Aug 29, 2022 · PreprintGenetics

Environmentally-induced epigenetic conversion of a piRNA cluster

Karine Casier, Valérie Delmarre, Nathalie Gueguen, Catherine Hermant, Elise Viodé, Chantal Vaury, Stéphane Ronsseray, Émilie Brasset, Laure Teysset, Antoine Boivin

This paper shows that high temperature can induce a stable epigenetic conversion of a transgene cluster into an active piRNA-producing locus in flies, without maternal piRNA inheritance.

eLife · Mar 15, 2019Peer-reviewedGenetics