Gabriella Frosi

EpiATLAS provides a comprehensive collection of human reference epigenomes to advance epigenomic research and understanding of cellular function and disease.

The paper identifies sex-specific regulatory dynamics in adolescent brain development that may contribute to depression vulnerability through hormone-sensitive gene expression and chromatin accessibility patterns.

This study characterizes the human uncinate fasciculus using multimodal approaches, finding no group differences in histology but identifying differentially expressed genes and age-related changes.

The paper identifies a glucocorticoid-responsive gene network in the anterior cingulate cortex that moderates the link between early-life adversity and depression risk in adult females.

The paper develops EpiClass, a machine learning tool that predicts and corrects metadata for over 350,000 epigenomic datasets with high accuracy.

This study identifies differential chromatin architecture and risk variants in specific brain cell types associated with major depressive disorder.

The paper investigates how childhood abuse affects the locus coeruleus-noradrenergic system in post-mortem brain samples, finding reduced neuron density and differential gene expression in resilient individuals.