Tamzin Zawadzki

This paper presents a simplified Langendorff-based method for isolating adult mouse ventricular myocytes using syringe pump-driven perfusion, improving reproducibility and accessibility.

This study identifies altered intracellular calcium handling in HFpEF mice, showing elevated diastolic calcium and slowed clearance as key contributors to impaired relaxation and exercise tolerance.

The paper identifies mitochondrial defects in eliminated cells during early mouse development and shows that cell competition removes cells with mitochondrial DNA mutations and sequence changes.