Giulio Tononi

Measuring neuronal input-output operations in vivo with random access projection microscopy

This paper introduces SLAP2, a high-speed microscope for measuring submicron synapses and dendritic voltage in behaving mice, revealing nonlinear input-output amplification in neurons.

Neural Signatures of Conscious Experience During Sleep: A Serial Awakening Study Using High-Density EEG

This study identifies neural signatures of conscious experience during NREM sleep using high-density EEG and machine learning.

Induction of cortical ON/OFF periods in awake mice fulfills sleep functions

The paper induces ON/OFF cortical activity in awake mice to mimic sleep functions and shows it reduces sleep need and restores memory consolidation.

TI-Toolbox: An Open-Source Software for Temporal Interference Stimulation Research

TI-Toolbox provides an open-source platform for temporal interference stimulation research, integrating neuroimaging tools and workflows for preprocessing, modeling, and analysis.

Intrinsic Units: Identifying a system's causal grain.

This paper extends integrated information theory to identify intrinsic units by assessing cause-effect power at different grains in simulated systems.

Temporal Interference Stimulation Can Enhance or Disrupt Human Memory Encoding as a Function of Brain Location and Frequency

This paper investigates how temporal interference stimulation affects memory encoding in humans, finding that different frequencies and brain targets can either enhance or impair recall.

Behavioral and cortical arousal from sleep, muscimol-induced coma, and anesthesia by direct optogenetic stimulation of cortical neurons

This study shows that optogenetic stimulation of cortical neurons can awaken mice from sleep, coma, and anesthesia, indicating cortical sufficiency for arousal.

Neural correlates of pure presence

The paper investigates the neural correlates of pure presence (PP) in meditators using hdEEG, finding reduced gamma power and delta power compared to other states, aligning with Integrated Information Theory predictions.

An adversarial collaboration to critically evaluate theories of consciousness

A preregistered multimodal neuroimaging study across 256 human participants directly tests Integrated Information Theory against Global Neuronal Workspace Theory, confirming some predictions while revealing major empirical challenges for both.

A survey of neurophysiological differentiation across mouse visual brain areas and timescales

This paper uses Neuropixels recordings to analyze neurophysiological differentiation (ND) in mouse visual brain areas across timescales, finding higher ND for naturalistic stimuli and successful detection trials.

Sleep/wake changes in perturbational complexity in rats and mice

This paper validates the Perturbational Complexity Index (PCIst) in rats and mice, showing it reliably reflects consciousness states and is influenced by deep cortical layer stimulation.

Ultrastructural effects of sleep and wake on the parallel fiber synapses of the cerebellum

The paper investigates how sleep and wake affect parallel fiber synapses in Purkinje cells, finding that sleep increases 'naked' spines and alters branched synapse dynamics.

Measuring stimulus-evoked neurophysiological differentiation in distinct populations of neurons in mouse visual cortex

The paper measures stimulus-evoked neurophysiological differentiation in mouse visual cortex neurons across layers and areas, finding greater differentiation in specific layers and areas for unscrambled stimuli.

Distinct signatures of loss of consciousness during Focal Impaired Awareness versus Focal to Bilateral Tonic-Clonic seizures

The paper compares loss of consciousness mechanisms in focal impaired awareness and focal to bilateral tonic-clonic seizures using intracranial EEG data from patients.

Integrity of corpus callosum is essential for the cross-hemispheric propagation of sleep slow waves: a high-density EEG study in split-brain patients

Fear in dreams and in wakefulness: evidence for day/night affective homeostasis

This study investigates the relationship between fear in dreams and emotional responses during wakefulness, finding that more fear in dreams correlates with reduced fear responses in specific brain regions during wakefulness.

A fast and general method to empirically estimate the complexity of brain responses to transcranial and intracranial stimulations

The paper introduces PCIST, a fast method to estimate perturbational complexity of brain signals, validated on TMS/hd-EEG and SEEG data, showing comparable accuracy to the original PCI with improved speed and applicability.

Visual imagery and visual perception induce similar changes in occipital slow waves of sleep

The paper shows that visual experience during wakefulness affects slow wave activity in the occipital cortex during sleep, with internal visual imagery modulating these changes.

Regional low-frequency oscillations in human rapid-eye movement sleep

The paper identifies two types of low-frequency oscillations in human REM sleep and links them to distinct functional roles and generation mechanisms.

BOLD signatures of sleep

This paper identifies BOLD oscillations in fMRI that differentiate sleep from wake and correlate with spindles and slow waves.

Propofol-Induced Unresponsiveness is Associated with Impaired Feedforward Connectivity in the Cortical Hierarchy

This study shows propofol reduces evoked power and impairs feedforward connectivity in the cortical hierarchy during TMS.

Are The Neural Correlates Of Consciousness In The Front Or In The Back Of The Cerebral Cortex? Clinical And Neuroimaging Evidence

This paper reviews clinical and neuroimaging evidence to debate whether consciousness is linked to the frontal or posterior cortex.

Role of somatostatin-positive cortical interneurons in the generation of sleep slow waves

This study shows that somatostatin-positive cortical interneurons drive sleep slow waves by triggering neuronal OFF periods during NREM sleep.

The neural correlates of dreaming

The paper identifies a posterior cortical region with low-frequency activity decreases and high-frequency activity correlations with dream content during both NREM and REM sleep.

Stimulus set meaningfulness and neurophysiological differentiation: a functional magnetic resonance imaging study

This study uses fMRI to show that neural response differentiation, measured by Lempel-Ziv complexity, correlates with stimulus set meaningfulness, with movies showing the highest differentiation.