Yuliang Dong

Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human Immunosenescence

This study uses single-cell multi-omics to analyze transcript isoform and immune repertoire changes in aging human immune cells, identifying age-related molecular features in T cells and B cells.

Complete genome-derived metabolic interactions reveal impact of gut ecology on human health

This study uses complete genomes to model gut microbiome metabolic interactions, revealing ecological group dynamics linked to inflammatory bowel disease and improving disease diagnosis.

The genetic repertoire of the deep sea: from sequence to structure and function

This study analyzes the genetic diversity of the deep sea, linking protein structures to genetic variants and identifying biotechnologically relevant features.

Complete Genomes of Cultivated Gut Bacteria Reveal Mobile Genetic Element-Driven Functional Diversity with Therapeutic Implications

The paper presents a comprehensive compendium of fully circularized human gut bacterial genomes and reveals how mobile genetic elements drive functional diversity with therapeutic implications.

Deciphering the Cell-Specific Transcript Heterogeneity and Alternative Splicing during the Early Embryonic Development of Zebrafish

The paper uses single-cell long-read transcriptome sequencing to study transcript diversity and alternative splicing in zebrafish embryos, identifying cell populations with distinct splicing regulations during early development.

DNB-Based On-Chip Motif Finding (DocMF): a High-Throughput Method to Profile Different Types of Protein-DNA Interactions

The paper introduces DocMF, a high-throughput method to profile protein-DNA interactions, identifying PAM sequences for CRISPR systems and other DNA-binding proteins.