Chun Hei Li

TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles

This study shows TMEM55B and TMEM55A regulate lysosome distribution in neurons by affecting motor protein transport, with TMEM55B specifically promoting anterograde transport of LAMP1-positive organelles.

Spatiotemporal proteomics elucidates trafficking and localization of Neuroligins to the axon initial segment plasma membrane

The paper uses spatiotemporal proteomics to study the trafficking and localization of NLGN1 and NLGN2 to the axon initial segment, revealing distinct sorting mechanisms and functional roles.

The axonal ER couples translation and secretion machineries for local delivery of axonal transmembrane proteins to promote axonal development

The paper identifies a mechanism where axonal ER couples translation and secretion of transmembrane proteins to support axonal development.

Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons

The paper develops POTATOMap to study biosynthetic lysosomal protein trafficking in neurons, revealing domain-specific mechanisms and interactions.

Axonal ER tubules regulate local translation via P180/RRBP1-mediated ribosome interactions

This study identifies axonal ER tubules and P180/RRBP1 as regulators of local mRNA translation in axons, showing their role in ribosome interactions and proteome dynamics.

Real-Time Three-Dimensional Tracking of Single Vesicles Reveals the Abnormal Motion and Vesicle Pools of Synaptic Vesicles in Neurons of Huntington's Disease Mice

This study tracks synaptic vesicle dynamics in Huntington's disease mice, finding abnormal motion and vesicle pools, which are partially rescued by Rab11 overexpression and jasplakinolide.