Matthew L. Kutys

Dynamics of ML-based Morphological Features Indicate a Shear Stress-Dependent Bifurcation of hiPSC-Derived Endothelial Cell States

The paper uses ML to analyze morphological dynamics of hiPSC-derived endothelial cells under shear stress, identifying a bifurcation between two stable cell states.

Perivascular matrix densification dysregulates angiogenesis and activates pro-inflammatory endothelial cells

This study shows that perivascular matrix densification promotes fibrosis by activating pro-inflammatory endothelial cells through a novel VE-cadherin-TGF-βR2 axis.

FAM83H couples keratin organization to Notch signaling during epidermal morphogenesis

This study identifies FAM83H as a regulator linking keratin organization to Notch signaling in epidermal morphogenesis, showing its role in keratinocyte differentiation and cell-cell adhesion.

JCAD couples tight junction condensates to actin and RhoA to maintain the endothelial barrier

This study identifies JCAD as a scaffold that links tight junction condensates to actin and RhoA, enabling endothelial barrier adaptation to inflammation.

StrataChip: a microphysiological system capturing dynamic keratinocyte fate and mechanical transitions during human epidermal morphogenesis

StrataChip enables dynamic study of human epidermal morphogenesis by integrating microfluidics with single-cell RNA-sequencing and imaging, revealing transcriptional and mechanical transitions during stratification.

Scrib organizes cortical actomyosin clusters to maintain adherens junctions and angiogenic sprouting

The paper identifies Scrib's role in organizing cortical actomyosin clusters to stabilize adherens junctions and support angiogenic sprouting.

The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress

The paper identifies a flow-specific Notch1 mechanotransduction pathway involving receptor polarization, endocytosis, and proteolytic activation in response to fluid shear stress.

Quantitative Comparison of Monomeric StayGold Variants Using Protein Nanocages in Living Cells

The paper compares monomeric StayGold variants using protein nanocages in living cells, finding mStayGold is 3-fold brighter and more photostable than EGFP and other variants.