Author

Niklas B. Thompson

University of Chicago Medicine Comprehensive Cancer CenterORCID 0000-0003-2745-4945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Austin T. Klein· 1 shared Daniel James McGrailiD· 1 shared Hardik ShahiD· 1 shared Heather S. Carr· 1 shared Issam Ben‐SahraiD· 1 shared John M. AsaraiD· 1 shared Marc L. MendilloiD· 1 shared Mushtaq Ahmad NengrooiD· 1 shared

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2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Austin T. Klein

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1 paper

Recent·Most cited

BiochemistryMolecular CellPeer-reviewedOct 28, 2025

Succinate dehydrogenase activity supports de novo purine synthesis

Mushtaq Ahmad Nengroo, Austin T. Klein, Heather S. Carr…·Issam Ben‐Sahra

This study shows that succinate dehydrogenase supports de novo purine synthesis in cancer cells, and its inhibition reduces proliferation by impairing purine biosynthesis and inducing a compensatory salvage pathway.

18 citationstop 3%

humanmetabolomics

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