Author

Austin T. Klein

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Daniel James McGrailiD· 1 shared Hardik ShahiD· 1 shared Heather S. Carr· 1 shared Issam Ben‐SahraiD· 1 shared John M. AsaraiD· 1 shared Marc L. MendilloiD· 1 shared Mushtaq Ahmad NengrooiD· 1 shared Nidhi SahniiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Daniel James McGrailORCID

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1 paper

Recent·Most cited

Succinate dehydrogenase activity supports de novo purine synthesis

Mushtaq Ahmad Nengroo, Austin T. Klein, Heather S. Carr, Olivia Vidal-Cruchez, Umakant Sahu, Daniel James McGrail, Nidhi Sahni, Niklas B. Thompson, Peter Allen Faull, Peng Gao, John M. Asara, Hardik Shah, Marc L. Mendillo, Issam Ben‐Sahra

This study shows that succinate dehydrogenase supports de novo purine synthesis in cancer cells, and its inhibition reduces proliferation by impairing purine biosynthesis and inducing a compensatory salvage pathway.

Molecular Cell · Oct 28, 2025Peer-reviewedBiochemistry