Wei Xiong Wen

This paper introduces a hierarchical GAMLSS framework for harmonizing and modeling neuroimaging data across multiple cohorts, showing improved removal of cohort effects and preservation of biological signals.

The paper examines associations between grey matter volumes and white matter hyperintensities with cognitive empathy measures in oldest-old adults, finding significant links between specific brain regions and different empathy assessment methods.

This paper introduces an enhanced cVAE-based normative model for neuroimaging data, showing comparable performance to existing methods while capturing individual deviations related to hypertension severity.

The paper evaluates factors affecting brain-age prediction models using structural neuroimaging data from 35,683 individuals, finding optimal model performance with no site harmonization, age-binning, and a sample size of over 1,600.

The paper examines age-related variations in cortical thickness across different life stages using gene expression data from a large neuroimaging dataset.

This study examines brain structural covariances in the ageing brain using UK Biobank data, finding age-related changes in cortical thickness and subcortical volume correlations, with sex differences and associations with cognition and longevity.

The paper examines age and sex effects on brain network topology in older adults and links these to cognitive performance using UK Biobank data.

This study identifies genetic variants associated with brain functional network measures in UK Biobank participants, linking them to sleep and psychiatric traits.

This study examines age-related changes in PSMD across the adult lifespan using multi-cohort diffusion tensor imaging data, finding PSMD increases consistently while other metrics show different age patterns.

This study identifies genetic variants linked to longitudinal brain structure changes across the lifespan using MRI data from 15,640 individuals.

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.

This study identifies three latent patterns linking age, education, and functional brain networks in healthy older adults, showing age affects core cognitive processes while education influences distinct networks.