The paper evaluates factors affecting brain-age prediction models using structural neuroimaging data from 35,683 individuals, finding optimal model performance with no site harmonization, age-binning, and a sample size of over 1,600.

Human Brain Mapping · Jul 1, 2024Peer-reviewedBioinformatics

Normative Modeling of Brain Morphometry Across the Lifespan using CentileBrain: Algorithm Benchmarking and Model Optimization

Ruiyang Ge, Yuetong Yu, Yi Xuan Qi, Yunan Vera Fan, Shiyu Chen, Chuntong Gao, Shalaila S. Haas, Amirhossein Modabbernia, Faye New, Ingrid Agartz, Philip J. Asherson, Rosa Ayesa‐Arriola, Nerisa Banaj, Tobias Banaschewski, Sarah Baumeister, , Bernd Weber

The paper benchmarks and optimizes a normative modeling framework for brain morphometry across the lifespan using MFPR, showing excellent accuracy and stability.

bioRxiv · Jan 30, 2023 · PreprintBioinformatics

Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages

Amirhossein Modabbernia, Dídac Vidal-piñeiro A, Ingrid Agartz, Ole A. Andreassen, Rosa Ayesa‐Arriola, Alessandro Bertolino, Dorret Irene Boomsma, Josiane Bourque, Alan F. Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Erick Jorge Canales-Rodríguez, Xavier Caseras, Patricia Conrod, , Sophia Frangou

The paper examines age-related variations in cortical thickness across different life stages using gene expression data from a large neuroimaging dataset.

bioRxiv · Mar 21, 2022 · PreprintNeuroscience

Age-related changes of Peak width Skeletonized Mean Diffusivity (PSMD) across the adult life span: a multi-cohort study

Grégory Beaudet, Ami Tsuchida, Laurent Petit, Christophe Tzourio, Svenja Caspers, Jan Schreiber, Zdenka Pausová, Yash Patel, Tomáš Paus, Reinhold Schmidt, Lukas Pirpamer, Perminder Singh Sachdev, Henry Brodaty, Nicole A. Kochan, Julian Norman Trollor, , Bernard M. Mazoyer

This study examines age-related changes in PSMD across the adult lifespan using multi-cohort diffusion tensor imaging data, finding PSMD increases consistently while other metrics show different age patterns.

Frontiers in Psychiatry · May 4, 2020Peer-reviewedNeuroscience

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Tianye Jia, Congying Chu, Yun Liu, Jenny van Dongen, Evangelos Papastergios, Nicola J. Armstrong, Mark E. Bastin, Tania Carrillo‐Roa, Anouk den Braber, Mathew A. Harris, Rick Jansen, Jingyu Liu, Michelle Luciano A, Anil P. S. Ori, Roberto Roiz‐Santiáñez, , Sylvane Desrivières

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.

Molecular Psychiatry · Dec 6, 2019Peer-reviewedGenomics

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

Nicola J. Armstrong, Karen A. Mather, Muralidharan Sargurupremraj, Maria J. Knol, Rainer Malik, Claudia Liliana Satizábal, Lisa R. Yanek, Wen Wei, Vilmundur G. Gudnason, Nicole D Deuker, Lloyd T. Elliott, Edith Hofer, Neda Jahanshad, Shuo Li, Mark W. Logue, , Paul Nyquist

This study identifies genetic loci specific to periventricular and deep white matter hyperintensities, revealing distinct genetic architectures and potential biological mechanisms.

bioRxiv · Jun 27, 2019 · PreprintNeuroscience

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

Edith Hofer, Gennady V. Roshchupkin, Hieab H.H. Adams, Maria J. Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J. Armstrong, Claudia Liliana Satizábal, Manon Bernard, Joshua C. Bis, Nathan A. Gillespie, Michelle Luciano A, Aniket Mishra, , Marcio Almeida

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.

bioRxiv · Jun 19, 2019 · PreprintGenetics

Planar cell polarity pathway and development of the human visual cortex

Jean Shin, Shaojie Ma, Edith Hofer, Yash Patel, Gennady V. Roshchupkin, André M. M. Sousa, Xueqiu Jian, Rebecca Gottesman, Thomas H. Mosley, Myriam Fornage, Yasaman Saba, Lukas Pirpamer, Reinhold Schmidt, Helena Schmidt, Amaia Carrión-Castillo, , Shareefa Dalvie

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.

bioRxiv · Apr 25, 2019 · PreprintNeuroscience