Michele Boiani

This study shows that fertilization can reverse the negative effects of maternal age on oocyte quality in mice, provided the fertilization environment is not aged.

This study shows that ZP2, a zona pellucida protein, is re-synthesized and functionally required in mouse embryos, playing an active role in blastocyst formation and cell lineage development.

The paper shows maternal CENP-C restores centromere symmetry in zygotes by asymmetrically recruiting to paternal centromeres, ensuring proper chromosome segregation.

The paper shows that the orientation of the first cleavage in mouse oocytes follows the shorter diameter of the unfertilized oocyte, leading to segregation of animal and vegetal hemispheres and explaining differences in monozygotic twins.

This study identifies a novel intracellular function of zona pellucida proteins in mice, showing they are critical for embryonic cell survival during the oocyte-to-embryo transition.

The paper compiles healthspan-related gene pathways in C. elegans and humans using literature review and molecular interaction data, identifying common themes like transcription and lipids.

The paper integrates multi-omics data to analyze gene expression dynamics in mouse embryos, revealing discrepancies between transcript and protein levels during early development.