Author

Emmanouil Zacharioudakis

Albert Einstein College of MedicineORCID 0000-0003-2781-9553Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Evripidis GavathiotisiD· 3 shared Agnese RazzoliiD· 1 shared Allan YarahmadyiD· 1 shared Ana María CuervoiD· 1 shared Anna SkwarskaiD· 1 shared Carlo CoronaiD· 1 shared Chloe Lopez-LeeiD· 1 shared Daohong ZhouiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

Evripidis GavathiotisORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologyCellsPeer-reviewedOct 8, 2025

Quiescent OXPHOS-high triple-negative breast cancer cells that persist after chemotherapy depend on BCL-XL for survival

Sławomir Andrzejewski, Marie Winter, Leandro Encarnação Garcia…·Eugen Dhimolea

This study identifies OXPHOS-high quiescent triple-negative breast cancer cells that survive chemotherapy and depend on BCL-XL for survival, showing that targeting BCL-XL enhances chemotherapy efficacy.

4 citations

humanbulk RNA-seq

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NeuroscienceNeuronPeer-reviewedSep 30, 2024

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

Gillian Carling, Li Fan, Nessa R. Foxe…·Li Gan

This study combines APOE4 and TREM2R47H in female tauopathy mice to identify pathways activated by AD risk factors, finding cGAS-STING signaling and microglial senescence as potential drivers.

85 citationstop 1%

mousestatistical model

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BiochemistrybioRxivPreprintApr 17, 2018

Direct Small Molecule Activation of Mitofusins

Emmanouil Zacharioudakis, Nikolaos Biris, Thomas P. Garner…·Evripidis Gavathiotis

This study identifies MASM7 as a direct activator of mitofusin 2, promoting mitochondrial fusion through conformational changes.

DOI 10.1101/301713

deep learningstatistical model

𝕏 PostBluesky