Selective quality control of mistargeted mitochondrial proteins at the endoplasmic reticulum
Yuichi Tsuchiya, Nikita Sergejevs, María Emilia Dueñas…·Pedro Carvalho
The paper identifies how mistargeted mitochondrial proteins are rerouted to the ER and cleared via ERAD, with MARCHF6 playing a central role in maintaining proteostasis during mitochondrial dysfunction.