Javier Eduardo Stern

A common Iba1 antibody labels vasopressin neurons in mice

The paper identifies that a goat anti-Iba1 antibody labels vasopressin neurons in mice, not microglia, highlighting the need for antibody validation.

Hypovolemia Evokes Conserved Inverse Neurovascular Coupling in the Supraoptic Nucleus Independent of Heart Failure

The paper shows hypovolemia triggers conserved inverse neurovascular coupling in the SON, similar to salt challenge, but this response is not reversed in heart failure like osmotic stimuli.

Asymmetric blood flow within a shared capillary network links the nucleus of the solitary tract and area postrema

The paper identifies an asymmetric blood flow pathway between the nucleus of the solitary tract and area postrema in rats, revealing structural and functional differences in their capillary networks.

Microglial Purinergic Signaling Underlies Salt-Induced Neurovascular Polarity Reversal in the Hypothalamus During Heart Failure

This study shows that microglial purinergic signaling reverses salt-induced neurovascular polarity in the hypothalamus during heart failure, restoring oxygen levels through adenosine A2A receptor-mediated vasodilation.

Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice.

This study identifies vagal afferents expressing the oxytocin receptor that mediate mechanosensation of the heart and gut, leading to hypometabolism and vigilance in mice.

Angiotensin-II drives changes in microglia-vascular interactions in rats with heart failure

This study shows that Angiotensin-II increases microglia-vascular interactions in rat heart failure models, leading to neuroinflammation that can be mitigated by blocking AngII receptors.

Impaired oxytocin signaling in the central amygdala in rats with chronic heart failure

This study investigates changes in the oxytocinergic circuit in the central amygdala of rats with chronic heart failure, finding impaired OT release and receptor function.

Blood flow directionality establishes the SCN as source and OVLT as target within a new vascular portal pathway

The paper identifies a new vascular portal pathway from the SCN to the OVLT, showing circadian-regulated blood flow and AVP transport, suggesting a mechanism for circadian signaling.

Analysis of the hypothalamic oxytocin system and oxytocin receptor-expressing astrocytes in a mouse model of Prader-Willi syndrome

This study examines the oxytocin system and OTR-expressing astrocytes in a mouse model of PWS, finding reduced oxytocin cells and OTR-expressing astrocytes in specific brain regions with sex-specific differences.

Altered PVN-to-CA2 hippocampal oxytocin pathway and reduced number of oxytocin-receptor expressing astrocytes in heart failure rats

The paper investigates changes in the PVN-to-CA2 oxytocin pathway in heart failure rats, finding altered oxytocinergic innervation and reduced OTR-expressing astrocytes.

Angiotensin II Inhibits the A-type K+ Current of Hypothalamic Paraventricular Nucleus Neurons in Rats with Heart Failure: Role of MAPK-ERK1/2 Signaling

This study investigates how angiotensin II modulates the A-type K+ current in PVN neurons via the MAPK-ERK pathway in rats with heart failure.

A novel analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray

The paper identifies a novel analgesic pathway involving parvocellular oxytocin neurons projecting to the vlPAG, which suppresses spinal cord sensory neuron activity and alleviates pain.

Oxytocin Acts on Astrocytes in the Central Amygdala to Promote a Positive Emotional State

This study shows that oxytocin acts on astrocytes in the central amygdala to promote a positive emotional state, challenging the notion that oxytocin only affects neurons.

A Multi-Gene Synaptic Plasticity Array Identifies Candidate Molecular Underpinnings Of Cognitive And Mood Deficits In Rats With Heart Failure

This study identifies molecular mechanisms of cognitive and mood deficits in rats with heart failure by analyzing synaptic plasticity gene expression in multiple brain regions.

Functional coupling between NMDA receptors and SK channels in rat hypothalamic magnocellular neurons: altered mechanisms during heart failure.

This study investigates the functional coupling between NMDA receptors and SK channels in rat hypothalamic neurons, finding reduced coupling in heart failure contributes to increased neuronal activity.