Author

Ralph Thomas Böttcher

Max Planck Institute of BiochemistryORCID 0000-0003-3050-7163Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

Reinhard FaessleriD· 2 shared André F. RendeiroiD· 1 shared Andreas VillungeriD· 1 shared Arnoud SonnenbergiD· 1 shared Barbara A. SteigenbergeriD· 1 shared Dharmendra PandeyiD· 1 shared Dieter LangoschiD· 1 shared Ernesto AbilaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

Reinhard FaesslerORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 28, 2026

Transmembrane-domain-driven heterodimer assembly licenses integrin head-domain folding in the endoplasmic reticulum

Jakob M. Reber, Dharmendra Pandey, Hannelore Meyer…·Shiny Shengzhen Guo

This study shows that transmembrane domain interactions in integrin β1-subunit are essential for proper folding and surface expression, with mutations disrupting these interactions causing functional impairments and embryonic lethality.

DOI 10.64898/2026.10.25.761699

mouseexperimental assay

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Cell BiologybioRxivPreprintMay 9, 2026

ILK binding to β1 Integrin is indirectly mediated by Kindlin-2

Susanne C. M. Reinhardt, Ralph Thomas Böttcher, Florian Brod…·Reinhard Faessler

This study resolves the debate on how ILK binds to β1 integrin by showing ILK is recruited via K2, not directly, using interdisciplinary methods.

DOI 10.64898/2026.05.06.723202

humanproteomics

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Cell BiologybioRxivPreprintJun 23, 2025

Sequential PIDD1 auto-processing is essential for ploidy control in liver and heart

Felix Eichin, Valentina C. Sladky, Matthäus A. Reiner…·Andreas Villunger

This study shows that sequential auto-processing of PIDD1 is essential for controlling ploidy in liver and heart development, with distinct roles for caspase-2 in different cell types.

3 citations

mouseexperimental assay

𝕏 PostBluesky