Felix Eichin

Ex Vivo Assay for Organ-Specific Cancer Cell Invasion

This paper develops an ex vivo model using organ-derived ECM scaffolds to study cancer cell invasion, showing organ-specific invasion patterns that match clinical observations.

Plasmalogen metabolism shapes germinal center immunity

This study shows that plasmalogen metabolism, via PEDS1, influences germinal center B cell function and IgG1 production, with implications for humoral immunity and hematopoiesis.

The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development

This study shows the PIDDosome restricts cardiomyocyte polyploidization during postnatal heart development through p21/Cdkn1a, independent of p53.

tRNA thiolation defects disrupt cellular proteostasis and tissue homeostasis in mammals

This study shows that tRNA thiolation defects in humans cause proteostasis and tissue homeostasis issues, but mice with similar defects develop normally.

Sequential PIDD1 auto-processing is essential for ploidy control in liver and heart

This study shows that sequential auto-processing of PIDD1 is essential for controlling ploidy in liver and heart development, with distinct roles for caspase-2 in different cell types.

SAFB2 enables the processing of suboptimal stem-loop structures in clustered primary miRNA transcripts

The paper identifies SAFB2 as a co-factor enabling the processing of suboptimal miRNA stem-loop structures in clustered primary transcripts.