Laura E. McKillop

Somnotate is a probabilistic classifier that improves sleep stage annotation in mice by identifying intermediate states and transitions, outperforming human experts.

This study shows that clozapine-N-oxide and compound 21 affect sleep in mice, suggesting that chemogenetic actuators may have off-target effects beyond DREADD receptor activation.

This study shows that silencing specific cortical neurons in mice increases wakefulness and reduces sleep rebound after deprivation, highlighting the cortex's role in sleep regulation.

This study shows that different types of waking experiences in mice affect sleep pressure differently, with task-based wakefulness reducing sleep need more than exploratory behavior.

This study shows that hypothalamic stimulation increases cortical activity and accelerates sleep pressure buildup, indicating the hypothalamus regulates both state transitions and within-state arousal intensity.

This study develops mathematical models of sleep homeostasis in mice, showing Process S integrates local cortical neuronal activity over time to regulate sleep quantity.