A role for the cortex in sleep-wake regulation

Lukas B. Krone; Tomoko Yamagata; Cristina Blanco‐Duque; Mathilde C. C. Guillaumin; Martin C. Kahn; Vincent van der Vinne; Laura E. McKillop; Shu K. E. Tam; Stuart N. Peirson; Colin J. Akerman; Anna Hoerder‐Suabedissen; Zoltán Molnár; Vladyslav V. Vyazovskiy

doi:10.1038/s41593-021-00894-6

NeuroscienceNature NeuroscienceAug 2, 2021

Peer-reviewed journal article

A role for the cortex in sleep-wake regulation

Lukas B. Krone iD, Tomoko Yamagata iD, Cristina Blanco‐Duque iD, Mathilde C. C. Guillaumin iD, Martin C. Kahn iD, Vincent van der Vinne iD, Laura E. McKillop iD, Shu K. E. Tam iD, Stuart N. Peirson iD, Colin J. Akerman iD, Anna Hoerder‐Suabedissen iD, Zoltán Molnár iD, Vladyslav V. Vyazovskiy iD

Abstract

The cortex and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global control of vigilance states. Here we silenced a subset of cortical layer 5 pyramidal and dentate gyrus granule cells in mice using a cell-specific ablation of the key t-SNARE protein SNAP25. We found a marked increase in wakefulness accompanied by a reduced rebound of EEG slow-wave activity after sleep deprivation. Our data illustrates an important role for the cortex in both global state control and sleep homeostasis.

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